Demonstration and Distribution of Kassinin-Like Material (Substance K) in the Rat Central Nervous System
- 1 August 1985
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 45 (2) , 552-558
- https://doi.org/10.1111/j.1471-4159.1985.tb04023.x
Abstract
Antiserum was raised against kassinin in rabbits. Cross-reactivity with other tachykinins was determined; these included substance K (100%) and substance P (0.1%). Peptides extracted from rat brain and synthetic tachykinins were chromatographed by reverse-phase HPLC. The major peak of kassinin-like material eluted at a time different from that of synthetic kassinin, eledoisin, physalaemin, neurokinin β, and substance P but coeluted with substance K. Measurement of kassinin-like material in macrodissected and microdissected brain regions indicated that the distribution of kassinin-like material was similar to that of substance P.Keywords
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