Effect of Physostigmine on Constructional and Memory Tasks in Alzheimer's Disease
- 1 August 1979
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 36 (8) , 501-503
- https://doi.org/10.1001/archneur.1979.00500440071014
Abstract
• We performed a double-blind study of the effect of physostigmine vs saline on the performance of memory and constructional tasks in a patient with probable Alzheimer's disease. On the days of physostigmine administration, a remarkable improvement in copying figures was observed. However, physostigmine administration had only a limited effect on memory performance. The results are interpreted in the context of recent biochemical studies of the brain in Alzheimer's disease, which suggest selective loss in the central cholinergic system.Keywords
This publication has 2 references indexed in Scilit:
- Memory Enhancement After Physostigmine Treatment in the Amnesic SyndromeArchives of Neurology, 1977
- Selective reminding for analysis of memory and learningJournal of Verbal Learning and Verbal Behavior, 1973