Selective Voltammetric and Amperometric Detection of Uric Acid with Oxidized Diamond Film Electrodes
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- 3 March 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 72 (7) , 1724-1727
- https://doi.org/10.1021/ac990862m
Abstract
Electrochemically anodized diamond film electrodes were used for selective detection of uric acid (UA) in the presence of high concentrations of ascorbic acid (AA) by differential pulse voltammetry and chronoamperometry. Because the oxidation peak potential for AA is ∼450 mV more positive than that for UA at anodized diamond electrodes, UA can be determined with very good selectivity. By use of chronoamperometry, linear calibration curves were obtained for UA over the concentration range up to 1 × 10-6 M in 0.1 M HClO4 solution, with the lowest experimental value measured being 5 × 10-8 M. This is consistent with the fact that a statistical analysis of the calibration curve yielded a detection limit of 1.5 × 10-8 M (S/N = 3). AA in less than 20-fold excess does not interfere. The practical analytical utility of the method is demonstrated by the measurement of UA in human urine and serum without any preliminary treatment.Keywords
This publication has 24 references indexed in Scilit:
- Introduction of Oxygen-Containing Functional Groups onto Diamond Electrode Surfaces by Oxygen Plasma and Anodic PolarizationElectrochemical and Solid-State Letters, 1999
- Selective Electrochemical Detection of Dopamine in the Presence of Ascorbic Acid at Anodized Diamond Thin Film ElectrodesElectrochemical and Solid-State Letters, 1999
- Cathodic and Anodic Deposition of Mercury and Silver at Boron‐Doped Diamond ElectrodesJournal of the Electrochemical Society, 1999
- Oxidation of Azide Anion at Boron-Doped Diamond Thin-Film ElectrodesAnalytical Chemistry, 1998
- Selective voltammetric method for uric acid detection using pre-anodized Nafion-coated glassy carbon electrodesThe Analyst, 1998
- A Selective Voltammetric Method for Uric Acid and Dopamine Detection Using Clay-Modified ElectrodesAnalytical Chemistry, 1997
- Morphological and Microstructural Stability of Boron‐Doped Diamond Thin Film Electrodes in an Acidic Chloride Medium at High Anodic Current DensitiesJournal of the Electrochemical Society, 1997
- Determination of ascorbic acid in a mixture of ascorbic acid and uric acid at a chemically modified electrodeAnalytica Chimica Acta, 1997
- Enhanced Signal-to-Background Ratios in Voltammetric Measurements Made at Diamond Thin-Film Electrochemical InterfacesAnalytical Chemistry, 1996
- An improved voltammetric method for the determination of trace amounts of uric acid with electrochemically pretreated carbon paste electrodesTalanta, 1994