Variation of Commercial Diisopropyl Fluorophosphate Preparations in Toxicological Studies

1 January 1983

journal article
research article
Published by Taylor & Francis in Drug and Chemical Toxicology

Vol. 6 (5) , 421-427
https://doi.org/10.3109/01480548309014164

Abstract

The variation of three diisopropyl fluorophosphate (DFP) lots obtained from two sources was investigated. The effects of different lots of DFP on body weight, mortality, and brain acetylcholinesterase activity in rats varied significantly. The in vitro effects of these DFP preparations on brain acetylcholinesterase activity also were markedly different. It appears that different commercial preparations of DFP possess different potencies and that the same apparent doses of different DFP preparations will not produce the same effects upon any physiological system under study.

Keywords

This publication has 3 references indexed in Scilit:

Metabolism of Organophosphorus Anticholinesterase Agents
Published by Springer Nature ,1963
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Biochemical Pharmacology, 1961
ALKYL FLUOROPHOSPHONATES: PREPARATION AND PHYSIOLOGICAL PROPERTIES
Published by Springer Nature ,1946