Prenatal diagnosis of Duchenne muscular dystrophy by DNA analysis.
Open Access
- 1 December 1986
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 23 (6) , 556-559
- https://doi.org/10.1136/jmg.23.6.556
Abstract
Linkage studies have been carried out in 20 families segregating for Duchenne muscular dystrophy and eight prenatal diagnoses performed, including six first trimester diagnoses and one twin pregnancy. The results of the restriction fragment length polymorphism (RFLP) analysis suggest that not all the possible RFLPs need to be used and a strategy for carrier detection studies is proposed.This publication has 5 references indexed in Scilit:
- Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophyNature, 1986
- Molecular genetics of the human X chromosome.Journal of Medical Genetics, 1985
- Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segmentNature, 1985
- PRENATAL DIAGNOSIS AND CARRIER DETECTION OF DUCHENNE MUSCULAR DYSTROPHY WITH CLOSELY LINKED RFLPsThe Lancet, 1985
- Report of the committee on the genetic constitution of the X and Y chromosomesCytogenetic and Genome Research, 1985