Turbidity, Birefringence, and Fluorescence Changes in Skeletal Muscle Coincident with the Action Potential

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Abstract
Electrical stimulation of frog striated muscle was found to produce transient changes in turbidity, birefringence, and fluorescence (of fibers stained with pyronine B). The initial phase of these optical changes was coincident with the action potential. These findings suggest that there is a macromolecular conformational change in muscle membrane during excitation.