Mixed Mullerian tumors of the uterus: Clinical and pathologic correlations

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Abstract
Cases (61) of mixed Muellerian tumors were reviewed. The patients had a mean age of 63.7 yr and the similar constitutional factors of diabetes mellitus, hypertension and nulliparity of endometrial adenocarcinoma. Only 1 patient had estrogen exposure; 18% had had prior exposure to pelvic radiation. The life table survival of the 61 patients was 41.1% at 5 yr. The 2-yr life table survival was 76% for disease confined to the uterus and 16.5% for extrauterine disease. There was no difference in survival between homologous and heterologous tumors. The surgical staging and the autopsies reviewed documented widely disseminated disease even when the tumor appeared to be confined to the uterus. To improve survival these patients requires aggressive staging and consideration of systemic adjuvant chemotherapy.

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