Amniotic Fluid Phospholipid Concentrations in Pregnancies with Pre-Eclampsia and/or Intrauterine Growth-Retardation of the Fetusxs

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Abstract
Amniotic fluid lecithin/sphingomyelin (L/S) ratios were examined in 74 samples from 65 patients with preeclampsia. The median values were comparable to those obtained in a reference series up to 36 weeks of gestation, whereas the median values after 37 weeks of gestation were found to be significantly smaller in the preeclamptic group (p<0.01). According to the present results a L/S ratio 2 would in fact guarantee no development of respiratory distress syndrome (RDS) in the infants of preeclamptic mothers. On the contrary L/S ratios s 1.6 may be of limited predictive value in these women since only Vy of the children developed RDS. When preeclampsia was combined with intrauterine growth-retardation of the fetus, RDS was found to be less apt to develop. In 21 samples of amniotic fluid from 13 women with idiopathic intrauterine growth-retardation of the fetus the L/S ratios were significantly below those in the reference series (p<0.05). No case of RDS was observed.

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