FAILURE OF OVULATION AFTER ADMINISTRATION OF STEROID HORMONES AND HORMONE ANTAGONISTS TO FEMALE RATS DURING THE NEONATAL PERIOD

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Abstract
The administration of testosterone propionate (TP) to female rats during the neonatal period results in a failure of ovulation as adults. Oestrogens also have this effect and it is possible that it is oestrogen produced from an androgenic precursor that normally acts upon the brain in the male rat (Brown-Grant, 1973). In support of this idea McDonald & Doughty (1972) found that the antioestrogen MER 25 (MER) could prevent the failure of ovulation that would otherwise have followed the administration of TP. Their rats were only studied up to 110 days of age, however, and it is known that the anovulatory state may develop later (Gorski, 1971). Also, if oestrogen is the active agent, it is difficult to see why an antiandrogen should protect the animals against the effects of TP administration though it has been suggested (Brown-Grant, 1973) that the agent commonly used, cyproterone acetate (CA), might be effective

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