Oxaziridines as Possible Intermediates in Flavin Monooxygenases
- 1 July 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (7) , 2646-2650
- https://doi.org/10.1073/pnas.71.7.2646
Abstract
The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed "carbonyl oxide" and flavin peroxide models are discussed.Keywords
This publication has 11 references indexed in Scilit:
- Spectral Properties of an Oxygenated Luciferase—Flavin Intermediate Isolated by Low-Temperature ChromatographyProceedings of the National Academy of Sciences, 1973
- The Mechanism of Action of the Flavoprotein Melilotate HydroxylaseJournal of Biological Chemistry, 1973
- p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate.1972
- Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase.1969
- Nature and Mechanisms of OxygenasesScience, 1969
- Electronic structures of lumazines and isoalloxazinesBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Crystalline l-Lysine OxygenaseJournal of Biological Chemistry, 1966
- Crystallization and Properties of p-Hydroxybenzoate Hydroxylase from Pseudomonas putidaJournal of Biological Chemistry, 1966
- SALICYLATE HYDROXYLASE A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE .I. PURIFICATION GENERAL PROPERTIES1965
- MECHANISM OF ACTION AND CRYSTALLIZATION OF LACTIC OXIDATIVE DECARBOXYLASE FROM MYCOBACTERIUM PHLEIJournal of Biological Chemistry, 1957