Hemoglobins A and A 2 in New World Primates: Comparative Variation and Its Evolutionary Implications
- 12 December 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3911) , 1428-1431
- https://doi.org/10.1126/science.166.3911.1428
Abstract
Hemoglobin A 2 (α 2 δ 2 ) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A 2 exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (α 2 β 2 ), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in δ than in β. Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly neutral gene.Keywords
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