Effect of Fluoridated Milk and Water on Enamel Fluoride Content and Dental Caries in the Rat

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Abstract
The effects of pre-eruptive and post-eruptive exposure to fluoride (F) administered in milk and in water were studied separately using Osborne-Mendel rats fed diet 2000 and infected by Streptococcus mutans 6715. In assessing pre-eruptive effects, 2 groups of animals received milk or water containing F at a dose of 1 mg/kg body weight by stomach tube from 5-15 days of age. Although these animals showed a significant increase in enamel uptake of F, their caries scores did not differ from those of untreated controls. In a 2nd experiment, where post-eruptive effects were assessed, animals which drank 3 ml of milk or water containing 50 ppm F 5 days/wk for 8 wk also showed a significant increase in enamel F. The increase was slightly greater when the F was provided in milk than when it was in water. The post-eruptive administration of F resulted in significantly reduced levels of buccal-lingual caries but without effect on proximal or sulcal surfaces. There were no differences between the use of milk or water as the vehicle with respect to caries scores.

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