Dynamic of the Placental Transfer of Digoxin in the Dog

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Abstract
The dynamic of the placental transfer of digoxin has been studied in 12 pregnant dogs. 3H-digoxin was administered intravenously in 4 animals for 3 h. Specimens of blood were simultaneously collected from the mother and one fetus every 15 min and their radioactivity compared. Maternal and fetal ECG and arterial pressure were also recorded. The digoxin was given to 8 dogs for 3 different periods: (1) 3–4 days, (2) 8–10 days, (3) 12–14 days. Plasma concentration of digoxin of fetuses and mothers were calculated by the radio-immuno-assay technique. The study shows that digoxin enters the umbilical circulation soon after its appearance in the maternal blood; fetal plasma concentrations remain lower than the maternal for at least 4 days; however, the digitahzation effect can be observed on the fetal ECG within 3 h after administration of toxic doses of digoxin to the mother.

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