SINGLE-DOSE ANTIBIOTIC-PROPHYLAXIS IN HIGH-RISK PATIENTS UNDERGOING CESAREAN-SECTION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 65  (5) , 655-657
Abstract
A prospective, double-blind, placebo-controlled study was performed to determine the effectiveness of single-dose antibiotic prophylaxis in decreasing infectious complications after primary cesarean section. One hundred women at high risk for postoperative infectious morbidity were randomly assigned to receive either placebo or one 2-g dose of ceftizoxime at cord clamping. The incidence of endometritis in the antibiotic group was 6.0 vs. 24.5% in the placebo group (P < 0.05). The incidence of febrile morbidity in the group receiving 1 dose of ceftizoxime was 14.0 vs. 32.7% in the placebo group (P < 0.05). Single-dose ceftizoxime prophylaxis significantly reduced the incidence of endometritis and febrile morbidity in high-risk patients undergoing cesarean section.

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