Circadian time dependence of cisplatin urinary kinetics

Publisher Website
Google Scholar
Abstract
Free platinum urinary excretion kinetics after a 30 min infusion of 60 mg/m2 i.v. cis-diammine dichloroplatinum (C) were studied during 51 monthly courses of C therapy in 11 patients suffering from a variety of advanced malignancies. Each patient received half of his or her treatment course at 0600 h and 1800 h. Initial treatment time was randomly assigned and subsequent treatment times were alternated. Each C infusion was accompanied by 4100 ml 5% dextrose and 0.45% NaCl solution given i.v. Evening C infusion resulted in greater urine output, lower peak urinary platinum concentrations, and lower areas under the curve of cisplatin concentration. While the normal circadian rhythm characteristics of body temperature were not altered by changing the C infusion time, the circadian rhythm characteristics of urine volume 1 mo. after treatment were significantly disrupted by morning but not by evening C. Since the kinetics of certain drugs may be affected by the time of adminstration, kinetic studies should be performed and reported in a time-qualified fashion. It is reasonable to expect that, since kinetic parameters are important in determining drug toxicity and effect, these too may vary predictably during the day.

This publication has 1 reference indexed in Scilit: