Dissolution OP Nalidixic Acid Solid Dispersions 1. Nal-Hydrotropic salts and NAL-Hyrj systems

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Abstract
The effect of solid dispersion techniques on the dissolution rate of nalidixic acid powder was investigated. The thermodynanic parameters of all tested systems revealed a spontaneous reaction with no complex affinity to the drug. Hexamine and sodium citrate showed very powerful solubilizing capacity towards NAL powder. For piperazine citrate in spite of its low interaction with NAL in the aqueous phase, it proved to be efficient carrier in the solid dispersion system. Hyrj 59 caused the greatest enhancement in NAL dissolution rate of all carriers examined. After 5 minutes, the RDR of the four-fold NAL-HyrJ 59 co-precipitate system was 16.5 times the untreated drug.