Novel Modification of 5-Formyluracil by Cysteine Derivatives in Aqueous Solution
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 17 (1) , 131-141
- https://doi.org/10.1080/07328319808005164
Abstract
Reactivities of 5-formyl-2′-deoxyuridine (fdU) and its 5′-monophosphate (fdUMP) to amino acids, amines and thiol compounds in neutral aqueous solution have been studied to elucidate the postmodification of the 5-formyluracil (fU) moiety in cells. fdU and fdUMP specifically reacted with cysteine and its analogs to form thiazolidine derivatives. The reaction involved condensation of the formyl group of fU with both α-NH2 (or NH2 at the equevalent position) and SH groups of cysteine derivatives.Keywords
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