INTERACTIONS BETWEEN DIFFERENT BILE-SALTS IN THE BILIARY-EXCRETION OF THE RAT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 39  (1) , 139-152
Abstract
In rats, the simultaneous infusion of tauroursodeoxycholate and taurocholate resulted in a longer choleretic condition with higher total bile salt and taurocholate excretion rates than taurocholate infusion alone. A similar, but weaker, response was observed when taurodehydrocholate was simultaneously infused instead of tauroursodeoxycholate. The taurolithocholate-induced cholestasis was most markedly prevented when taurocholate, rather than tauroursodeoxycholate, was simultaneously infused. The effect of tauroursodeoxycholate on the biliary excretion of taurocholate appears to differ from that of taurocholate on taurolithocholate excretion.