CARDIOVASCULAR LESIONS IN SPRAGUE‐DAWLEY RATS INDUCED BY LONG‐TERM TREATMENT WITH CAFFEINE

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Abstract
Male Sprague-Dawley rats were treated with phenacetin, phenazone or caffeine in the diet or with combinations of these chemicals for up to 117 wk. Of 28 rats receiving caffeine, 20 developed moderate to severe myocardial fibrosis compared with 5 controls, in spite of the fact that controls had a 16 wk longer average life-span. Caffeine-treated rats (4) had histologic evidence of acute myocardial infarction which was not found in any other rats. Of rats treated with caffeine only or with caffeine and phenacetin in combination, 40% had periarteritis nodosa-like lesions in the mesenteric vessels. Rats (79%) treated with caffeine only and those treated with caffeine and phenacetin (52%) died from cardiovascular disease, compared with 17% of controls. Long-term administration of caffeine to Sprague-Dawley rats was associated with reduced life-span due to cardiovascular disease.

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