Influence of Acute Tissue Injury on in vitro Incorporation of 65Zn by Sheep Erythrocytes

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Abstract
Labeled zinc incorporation by erythrocytes of diseased or injured animals may reveal zinc-status information when borderline zinc deficiencies exist. The 65Zn uptake by red blood cells of skin-irradiated sheep was much greater than that of cells from control sheep, and factors affecting this uptake were studied. The increased 65Zn uptake was not influenced by the change in packed cell volume, nor could the uptake be altered by extracorporeal irradiation of the red blood cells. The nominal rate of 65Zn uptake during a 10-hr incubation period was .6% per hour for control cells and 1.4% per hour for cells from injured sheep. Hypoalbuminemia and hyperglobulinemia resulted from the irradiation injury, and this change in plasma composition could account for part, but not all, of the differences in uptake between cells from injured and control sheep. Significant differences between the cells from these two sources were still observed when the influence of the plasma was removed. These differences (1) could be due to an increased zinc permeability resulting from injury sustained by the cells as they circulated through injured tissue, or (2) may be associated with the role of zinc in would healing. Copyright © 1975. American Society of Animal Science . Copyright 1975 by American Society of Animal Science.

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