Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
- 1 February 1989
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 45 (2) , 209-211
- https://doi.org/10.1007/bf01954881
Abstract
Summary The African treeCombretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502–3 μM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50≈0.003 μM and human colon cancer cell lines [(e.g. LoVo (ED50=0.005 μg/ml), HT29 (ED50 0.02 μg/ml, Colo 205 (ED50=0.07 μg/ml), DLD-1 (ED50=0.005 μg/ml) and HCT-15 (ED50=0.0009 μg/ml)] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.Keywords
This publication has 3 references indexed in Scilit:
- Isolation, structure, and synthesis of combretastatin A-2, A-3, and B-2Canadian Journal of Chemistry, 1987
- Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrumJournal of Natural Products, 1987
- Isolation and structure of combretastatinCanadian Journal of Chemistry, 1982