Antigen-Antibody Reactions in Allergic Human Tissues

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Abstract
Summary: In antigen-challenged nasal mucosa of seasonal hay fever patients, antigen, presumably bound to antibody, was identified in the cytoplasm of mucosa and gland epithelial cells, in histiocytes, pericytes, capillary endothelial cells and fibrocytes. In histamine-challenged tissue coated with antigen in vitro, fluorescence was demonstrable in surface epithelium, in gland cells, histiocytes and pericytes, but not in fibrocytes or endothelial cells. Fluorescent staining also suggests the posible presence of antigen and antibody in eosinophils of the allergic nasal mucosa.

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