Primary Localized Amyloidosis of the Bladder: A Case of AL (λ) Amyloid Protein and Combination Therapy Using Dimethyl Sulfoxide and Cepharanthin

1 January 1992

journal article
case report
Published by S. Karger AG in Urologia Internationalis

Vol. 48 (2) , 228-231
https://doi.org/10.1159/000282340

Abstract

We report a case of primary localized amyloidosis of the bladder with amyloid deposits which was characterized as being of immunoglobulin light chain origin (AL) including Λ type (A Λ) and P component (AP) using the KMnO₄ pre-treatment method and immunohistochemical procedures. The patient was treated successfully with intravesical dimethyl sulfoxide instillation and oral administration of high-dose cepharanthin after transurethral resection. Combination therapy with dimethyl sulfoxide and cepharanthin was shown to be useful for primary localized amyloidosis of the bladder.

Keywords

VESICAL AMYLOIDOSIS
AL (Λ) AMYLOID PROTEIN
COMBINATION THERAPY
DIMETHYL SULFOXIDE
CEPHARANTHIN

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