Steady-state moxalactam pharmacokinetics in patients: Noncompartmental versus two-compartmental analysis

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Abstract
Moxalactam pharmacokinetics at steady state was examined in a group of 40 patients with presumed or proven abdominal sepsis. Mean steady-state serum concentrations ranged from 27.0 to 211.0 mcg/ml and correlated inversely with creatinine clearance (r=0.91, p (CL)displayed excellent correlation with creatinine clearance as 92%(r 2×100)of the variance in clearance could be accounted for by renal function (p< 0.0001). Pharmacokinetic parameters were estimated using noncompartmental analysis based on statistical moment theory. Noncompartmentally determined CLwas in agreement with CLdetermined by nonlinear least squares regression (r=0.99, p< 0.0001).Moxalactam total body clearance is best predicted from creatinine clearance corrected for body surface area.