Oligonucleotide Derivatives in Organism: Distribution Among Organs, Rates of Release and Degradation

1 January 1991

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 10 (1-3) , 523-525
https://doi.org/10.1080/07328319108046516

Abstract

Oligonucleotide derivatives were observed partially degraded in all tissues of mice 30 min post-injection. Conoentration in liver and kidney was 100-fold larger than in brain. Phosphorothioate oligos were more resistant than pho-sphodiesters.

Keywords

PHOSPHOROTHIOATE
TISSUES
FOLD
PARTIALLY
SPHODIESTERS
OLIGOS
BRAIN
CONOENTRATION
OLIGONUCLEOTIDE