Relationship between the biosynthesis of virus-like particles and mycophenolic acid in Penicillium stoloniferum and Penicillium brevi-compactum
- 1 November 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 19 (11) , 1459-1462
- https://doi.org/10.1139/m73-237
Abstract
Several strains of Penicillium stoloniferum and P. brevi-compactum containing no virus-like particles (VLP) synthesize mycophenolic acid (MA), an antiviral metabolite; one strain of P. stoloniferum producing more than 600 μg VLP/g dry weight mycelia synthesized no detectable MA. However, one strain of P. brevi-compactum produced 5 μg VLP/g dry weight plus MA. Preliminary data suggest that MA may act as an antivirus in controlling fungal virus infection or its replication, or both.Keywords
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