Change in α‐ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH

20 August 1990

journal article
Published by Wiley in FEBS Letters

Vol. 269 (1) , 252-254
https://doi.org/10.1016/0014-5793(90)81166-l

Abstract

Reducing 2 SH‐groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed.

Keywords

PROPERTIES DUE
KETOGLUTARATE DEHYDROGENASE
DEHYDROGENASE COOPERATIVE
DIHYDROLIPOATE
NADH
Α KETOGLUTARATE

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