New translocation involving homologous chromosome 3 in acute myelogenous leukemia (M2)
- 1 April 1993
- journal article
- case report
- Published by Wiley in American Journal of Hematology
- Vol. 42 (4) , 398-399
- https://doi.org/10.1002/ajh.2830420414
Abstract
An apparent balanced translocation involving the long arms of homologous chromosomes is described for the first time in a patient with acute myelogenous leukemia (AML) (M2), i.e., 46, XY, t(3;3) (q21;q26). After reviewing the literature, it was noted that a breakpoint involving band 3q26 is a frequent anomaly in other translocations. Thus, we are tempted to hypothesize that 3q26 band may also play an important role in the pathogenesis of AML (M2).Keywords
This publication has 5 references indexed in Scilit:
- Cytogenetic and clinical investigations in 76 cases with therapy-related leukemia and myelodysplastic syndromeCancer Genetics and Cytogenetics, 1989
- Preferential response of acute myeloid leukemias with translocation involving chromosome 17 to human recombinant granulocyte colony- stimulating factorBlood, 1988
- Combination of mitoxantrone and etoposide in refractory acute myelogenous leukemia--an active and well-tolerated regimen.Journal of Clinical Oncology, 1988
- Chromosome 3 abnormalities in acute nonlymphocytic leukemia (ANLL) with abnormal thrombopoiesis: report of three patients with a "new" inversion anomaly and a further case of homologous translocationBlood, 1982
- Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant diseaseBlood, 1981