HORMONAL AND BIOCHEMICAL CHANGES IN PATIENTS SUCCESSFULLY OPERATED FOR PRIMARY HYPERPARATHYROIDISM

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Abstract
Six patients with primary hyperparathyroidism were studied during the first 7 days after the operative removal of the parathyroid adenoma with special emphasis on biochemical and hormonal changes during the first 24 h. Serum parathyroid hormone (PTH) levels fell abruptly after parathyroidectomy and normalized within 3 h. The half-life of the biologically inert C-terminal PTH fragment (MW 7000-7500) was calculated to be about 180 min. No significant changes in serum calcitonin levels were found. The serum P levels, which were already low preoperatively, decreased transiently but significantly during the first 90 min after the removal of the parathyroid adenoma. This fall in serum P preceded a slow decrease of calcemia. During the 1st postoperative week calcemia continued to decline, while serum P levels increased. The preoperative cholesterol levels were low compared to age paired normal Belgians. During the 1st postoperative week cholesterolemia decreased even more; at long term follow-up a clearcut increase of the serum cholesterol levels must be expected.