Suppression of Immunoglobulin E-Mediated Anaphylactic Reaction byAlpinia Oxyphyllain Rats
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 22 (2) , 267-277
- https://doi.org/10.3109/08923970009016420
Abstract
We investigated the effect of Alpinia oxyphylla water extract (AOWE) on immunoglobulin E (IgE)-mediated anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody. AOWE dose-dependently suppressed passive cutaneous anaphylaxis (PCA) when intraperitoneally or orally administered. On the other hand, it showed weak suppressive activity when administred intravenously. AOWE dose-dependently suppressed anaphylactic histamine release from rat peritoneal mast cells (RPMC) activated by anti-DNP IgE antibody. However, AOWE had a significant augmenting effect on anti-DNP IgE antibody-induced tumor necrosis factor-α secretion from RPMC. These results indicated that AOWE may possess strong antianaphylactic action and also suggest that differential activity following administration routes may be caused by difference of bioavailability.Keywords
This publication has 18 references indexed in Scilit:
- Suppression ofl-Histidine Decarboxylase mRNA Expression by MethyleugenolBiochemical and Biophysical Research Communications, 1997
- Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: Characterization of factors influencing histamine releasabilityJournal of Allergy and Clinical Immunology, 1996
- The pharmacology and mechanisms of action of histamine H1‐antagonistsClinical and Experimental Allergy, 1990
- Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectinNature, 1990
- Histamine and its antagonists in asthmaJournal of Allergy and Clinical Immunology, 1989
- Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.The Journal of Experimental Medicine, 1989
- Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activationNature, 1989
- Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophoresNature, 1989
- Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.Proceedings of the National Academy of Sciences, 1977
- A Comparative Study of the Anti-Allergic Effects of Disodium Baicalein 6-Phosphate (BPS) and Disodium Cromoglycate (DSCG)The Japanese Journal of Pharmacology, 1977