Effect of verapamil on basal and pentagastrin-stimulated gastric acid secretion

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Abstract
The role of Ca in gastric acid secretion is still uncertain. The effect of verapamil on basal and pentagastrin-stimulated gastric acid secretion was evaluated in 8 normal men. Submaximal pentagastrin tests (2 .mu.g/kg per h) were performed after pretreatment with i.v. verapamil at a concentration of 0.1 mg/kg and followed 1 h later with a 2nd bolus injection of 0.15 mg/kg. On a separate day, subjects received a placebo injection of saline solution at the same designated times as the verapamil. Verapamil did not alter basal or stimulated gastric acid secretion. All subjects showed ECG evidence of significant Ca-channel blocking (i.e., prolongation of the PR interval). Therapeutic doses of Ca slow-channel antagonistic evidently do not alter gastric acid secretion in normal subjects. In vivo, secretory function of the human parietal cell is evidently not affected by alteration in cellular Ca flux.