DISPOSITION OF 13-CIS-RETINOIC ACID AND N-(2-HYDROXYETHYL)RETINAMIDE IN MICE AFTER ORAL DOSES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (4) , 391-398
Abstract
The concentrations of 13-cis-retinoic acid [13-cis-RA] and N-(2-hydroxyethyl)retinamide [N-HOERA] in serum and tissues from mice were measured after oral dosing with 10 mg/kg. Serum levels of the drugs reached their maxima within 15-30 min, and then declined in an exponential fashion with t1/2 [half-time] values of 19 min and 2.9 h, respectively. Tissue levels of 13-cis-RA reached their maxima within 15-30 min, then declined exponentially with t1/2 values of 11-19 min. Tissue levels of N-HOERA reached their maxima within 30 min to 2 h, then declined exponentially with t1/2 values of 2.1-4.7 h. Longer t1/2 values were observed for both 13-cis-RA and N-HOERA in the bladder (51 min and 7.3 h, respectively). Only small amounts of the unchanged retinoids were observed in bile and feces, and none was found in urine. Polar materials were present in bile, feces and urine. [Implications for the use of retinoids in the prevention of bladder carcinogenesis were discussed.].