SOME FACTORS AFFECTING TIME COURSE OF RECOVERY OF CONTRACTURE ABILITY FOLLOWING A POTASSIUM CONTRACTURE IN FROG STRIATED MUSCLE

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  • 1 January 1965
    • journal article
    • research article
    • Vol. 48  (6) , 975-+
Abstract
The recovery rate of contracture ability after a K contracture was shown to be initially dependent upon the rate of repolari-zation and later to be dependent upon a process which was sensitive to concentration and temperature changes in a manner consistent with chemical binding. It was shown qualitatively that repolarization does not depend on the presence of external calcium and the second process was studied by allowing the muscle to repolarize for 2 minutes in calcium-free solution following a K contracture. Recovery after this procedure is speeded by decreasing either the concentration of potassium in the contracture solution or its temperature and is slowed by solution either decreasing the calcium concentration, temperature or by increasing the duration of the exposure to potassium.