MIXED LYMPHOBLASTIC-MYELOMONOBLASTIC LEUKEMIA IN TREATED HODGKINS-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (1) , 129-133
Abstract
In a case of acute leukemia occurring 5.5 yr after diagnosis of Hodgkin''s disease, a mixture of lymphoid and myelomonocytoid blasts was identified by morphological, cytochemical and immunologic methods. The majority of blasts were characterized as lymphoid by their strong expression of nuclear terminal transferase (TdT) enzyme. In contrast, a minor blast population was identified as myelomonocytoid by the strong nonspecific esterase positivity and lack of TdT. The 2 distinct blast cell populations showed different sensitivity to the various chemotherapeutic protocols used.