EXOCRINE PANCREATIC FUNCTION-TEST BY A SYNTHETIC PEPTIDE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 71  (1) , 45-52
Abstract
A new synthetic substance, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, is specially cleaved by pancreatic chymotrypsin after oral administration and the released p-aminobenzoic acid (P.A.B.A.) is absorbed and excreted in the urine. The P.A.B.A. recovery in the urine was examined to evaluate its diagnostic value as an exocrine pancreatic function test. There is a significant correlation between this test and maximal bicarbonate concentration, amylase output and volume of P.Z./C.C.K. [pancreozymin-cholecystokinin] secretin test. More than 1/2-2/3 proximal or 1/3 distal of the pancreas must be removed before an abnormal result is noted in this test. This is a simple and useful test to detect exocrine pancreatic insufficiency of more than moderate degree but normal results may be obtained in minimal to mild exocrine pancreatic insufficiency. Only 6 of 11 cases (54.5%) with 1 abnormal factor of P-S test showed decreased P.A.B.A. recovery, whereas 22 of 23 cases (95.7%) with 2 or 3 abnormal factors of P-S test showed decreased or borderline P.A.B.A. recovery.

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