Distribution of Serotonergic Neurons in the Central Nervous System: A Peroxidase-Antiperoxidase Study with Anti-Serotonin Antibodies
Open Access
- 1 January 1983
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 31 (1A_suppl) , 181-185
- https://doi.org/10.1177/31.1a_suppl.6338102
Abstract
Distribution of serotonin (5-HT) neurons in the central nervous system (CNS) of various vertebrates was investigated with a highly sensitive immunohistochemical technique. Antibodies were raised in rabbits against an antigen prepared by coupling 5-HT to bovine thyroglobulin. 5-HT neurons were found to be distributed more widely and densely than has been heretofore described. Serotonergic neuronal somata are organized according to certain basic patterns, but there are interspecific differences with regard to the distribution of 5-HT fibers. The processes of 5-HT neurons form a dense plexus by ramification and anastomosis in almost all areas of the CNS, including the ventricular surfaces. In the light of our observations, Golgi's reticular theory may have to be revised.Keywords
This publication has 15 references indexed in Scilit:
- Immunohistochemical demonstration of serotonin nerve fibers in the cat neurohypophysisHistochemistry and Cell Biology, 1982
- Immunohistochemical Demonstration of the Organization of Serotonin Neurons in the Brain of the Monkey (Macaca fuscata)Cells Tissues Organs, 1982
- Immunohistochemical studies on the processes of serotonin neurons and their ramification in the central nervous system-with regard to the possibility of the existence of golgi's rete nervosa diffusa.Archivum histologicum japonicum, 1982
- Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminalsNeuroscience, 1981
- The distribution and orientation of serotonin fibers in the entorhinal and other retrohippocampal areasBrain Structure and Function, 1981
- The serotonin innervation of the cerebral cortex in the rat—an immunohistochemical analysisNeuroscience, 1980
- Radioautographic characterization of a serotonin-accumulating nerve cell group in adult rat hypothalamusBrain Research, 1979
- Localization of serotonin in the central nervous system by immunohistochemistry: Description of a specific and sensitive technique and some applicationsNeuroscience, 1978
- Indoleamine neurons and their processes in the normal rat brain and in chronic diet‐induced thiamine deficiency demonstrated by uptake of 3H‐SerotoninJournal of Comparative Neurology, 1977
- Serotonin content of the brain stem nuclei in the ratBrain Research, 1974