The Effect of Nitrogen Mustard Pretreatment on the Ultra-Violet-Induced Morphological and Biochemical Mutation Rate
- 1 September 1949
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 35 (9) , 513-518
- https://doi.org/10.1073/pnas.35.9.513
Abstract
Pretreatment of the microconidia of Neurospora crassa with a relatively non-mutagenic concn. of nitrogen mustard alters the stability of the genes in such a manner as to increase significantly the effectiveness of u.-v. in inducing morphological and biochemical mutations. It is suggested that the increased frequency of mutations results from an increased frequency of intra-genic rather than extra-genic (chromosomal) alterations.Keywords
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