Relations between Hepatotoxicity and Pharmacokinetics of Paracetamol in Rats and Mice

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Abstract
A dose-dependent increase of paracetamol serum half-life (t1/2) was found after oral and i.v. application in rats and oral application in mice. The hepatotoxic effects of paracetamol were not correlated with this prolongation of t1/2. Dithiocarb protected rats against paracetamol liver damage but did not change paracetamol t1/2. Paracetamol t1/2 was not influenced either by a hepatotoxic dose of CCl4. Apparently, the dose-dependent prolongation of paracetamol serum half-life is not due to paracetamol-induced liver damage but merely the consequence of saturated elimination processes.

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