A preliminary report on the use of Warfarin in the Treatment of Navicular Disease

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Abstract
Horses (20) suffering from navicular disease were treated with warfarin given orally. The dosage was to give a 2-4 s prolongation of the 1 stage prothrombin time (OSPT). Dosage was initially at a rate of 0.018 mg/kg, changing the dose by amounts of 20% until the required dose was achieved. Final dose rates varied from 0.012-0.75 mg/kg. All the cases treated received warfarin daily throughout the trial. Of the animals 17 became sound and the remaining 3 showed a marked improvement in their gait. The mean of the ages of the horses was 7.5 yr, the mean of the periods of lameness 9 mo. and the mean of the time taken to recovery once treatment was commenced was 7 wk.