Sequence and structure space of RNA‐binding peptides
- 31 July 2003
- journal article
- review article
- Published by Wiley in Biopolymers
- Vol. 70 (1) , 80-85
- https://doi.org/10.1002/bip.10429
Abstract
Studies of RNA‐binding peptides, and recent combinatorial library experiments in particular, have demonstrated that diverse peptide sequences and structures can be used to recognize specific RNA sites. The identification of large numbers of sequences capable of binding to a particular site has provided extensive phylogenetic information used to deduce basic principles of recognition. The high frequency at which RNA‐binding peptides are found in large sequence libraries suggests plausible routes to evolve sequence‐specific binders, facilitating the design of new binding molecules and perhaps reflecting characteristics of natural evolution. © 2003 Wiley Periodicals, Inc. Biopolymers, 2003Keywords
This publication has 42 references indexed in Scilit:
- Selection of RRE RNA binding peptides using a kanamycin antitermination assayRNA, 2003
- Sequence analysis of an artificial family of RNA‐binding peptidesProtein Science, 2002
- Anticodon Domain Methylated Nucleosides of Yeast tRNAPhe Are Significant Recognition Determinants in the Binding of a Phage Display Selected PeptideBiochemistry, 2001
- The Structure of the Coliphage HK022 Nun Protein-λ-phage boxB RNA ComplexPublished by Elsevier ,2001
- Structural characterization of the complex of the Rev response element RNA with a selected peptideChemistry & Biology, 2001
- Specific RNA Binding by a Single C2H2Zinc FingerPublished by Elsevier ,2001
- Specific RNA binding proteins constructed from zinc fingersNature Structural & Molecular Biology, 1998
- Phage Display of RNA Binding Zinc Fingers from Transcription Factor IIIAPublished by Elsevier ,1997
- Selection of RNA-binding peptides in vivoNature, 1996
- Major Groove Accessibility of RNAScience, 1993