Correlation between the hydrophobic nature of monosaccharides and cholates, and their hydrophobic indices

Abstract
Hydrophobic and hydrophilic surface areas, which are the surface areas occupied by CH and CH2 groups and by OH, COO and ether oxygen groups, respectively, are calculated for monosaccharides and cholates using the computer program developed by Hermann. Hydrophobic indices, defined by the surface-area ratio of the hydrophobic to hydrophilic groups, correlate well with the partition coefficients of the polystyrene–water system for monosaccharides and with values of the critical micelle concentration for cholates. These facts indicate that the concept of hydrophobic index is important in considering hydrophobic interactions of flat molecules in aqueous solutions.

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