Autosomal dominant cerebellar phenotypes

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Abstract
Neurologists have written extensively as to the appropriateness of various classifications and have debated, often passionately at meetings, the uniqueness and placement of newly evaluated families with inherited cerebellar disease. Categories of disease abound, therein satisfying the needs of selective investigators to be either unifiers or splitters, often based on quite arbitrary factors [1]. Scholarly, yet divergent, classifications of dominantly inherited syndromes have been formulated by Greenfield, [2] Konigsmark and Weiner, [3] Harding, [4] and the World Federation of Neurology Study Group on Cerebellar Ataxias (unpublished, 1993). Harding [4] separates the autosomal dominant cerebellar ataxias (ADCAs) into type I and type II, in which ataxia is combined to a varying degree with pyramidal and extrapyramidal signs …