Immune Response to Gross Virus- Induced Lymphoma. II. Kinetics of the Cellular Immune Response

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Abstract
Cellular immunity specifically directed against a transplantable, highly antigenic, syngeneic Gross virus-induced lymphoma in W/Fu rats was examined. A sensitive and quantitative in vitro method was used for detection of cellular cytotoxicity. Cellular immunity was first noted 3–5 days after immunization. This activity reached a peak at 9–10 days and gradually declined to low levels by day 14, regardless of persistence or regression of the tumor. The level of maximum cellular cytotoxic activity was related to the dose of tumor cells inoculated, but the time course of response was unaffected by changes in tumor inoculum. The peak of cellular immune activity occurred at about the same time as the first cytotoxic antibody peak. The second cytotoxic antibody peak was not accompanied by an increase in cellular immune activity. Increased cellular cytotoxicity could not be produced by inoculation of a second dose of tumor cells at 30–40 days after the initial inoculum. The relationship between the observed differences in cellular and humoral responses and tumor growth remains to be determined.

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