Limite De L’Antagonisme De La Penicilline G Et Du Chloramphenicol Sur Neisseria Meningitidis

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Abstract
By suitable constant method the antagonism of chloramphenicol and penicillin G may be demonstrated on Neisseria meningitidis. The study of the rate of bacteriocidal action of penicillin G and chloramphenicol alone and in combination shows : 1. The rate of action of penicillin G depends on the proliferation rate of meningococci; 2. In the logarithmic phase culture, the penicillin rate of action is practically independent of its concentration between 1 and 10 U/ml; 3. The bactericidal action of chloramphenicol is proportional to its concentration; 4. The antagonism between chloramphenicol and penicillin G occurs only with low concentrations of chloramphenicol (0,1-5 µg/ml) with a slow action rate; 5. The speed of action of chloramphenicol, at the concentration of 10 µg/ml, is rather the same as that of penicillin G; 6. The combination of 1 U penicillin G with 10 µg chloramphenicol has approximately the same rate of action as either of the substances alone. In the treatment of Neisseria meningitidis infection, the combination of penicillin G and chloramphenicol acts antagonistically only within certain limits. Concentrations beyond which this antagonism does not occur may theoretically be reached in cerebro-spinal fluid. In exceptional cases (pus, relapse) the use of chloramphenicol, in high dosage, may be justified from the microbiological point of view.

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