CYTOPHAGIC PANNICULITIS - AN INDEPENDENT FORM OF HISTIOCYTIC PANNICULITIS WITH FEVER, PANCYTOPENIA, POLYSEROSITIS, AND LETHAL HEMORRHAGIC DIATHESIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 31  (11) , 588-594
Abstract
Two [human] cases of what was originally called Weber-Christian disease were a chronic recurrent from of histiocytic panniculitis characterized by histiocytic engulfment of red and white blood cells, i.e., cytophagocytosis. The disease was manifested by recurrent fever, subcutaneous nodules, pancytopenia and mucosal ulcerations. Hepatosplenomegaly and enlarged lymph nodes were observed. Focal invasion of the RES by acidophilic or cytophagic histiocytes were identified. Progressive changes in liver function and hemorrhagic diathesis occurred in both patients.

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