I. Cardiovascular Disease—With Particular Attention to Atherosclerosis

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Abstract
The hypothesis is presented that the B-lipoproteins in plasma may be considered the agent of atherosclerosis. Evidence is martialed from studies of comparative biochemistry, studies of lipid disorders in man, and epidemiologic evidence regarding the distribution of coronary artery disease in various populations to support this view. This suggests that a prospective study in which serum lipoproteins, blood pressure, and weight are controlled in young men over a period of 20 years may provide further support for this hypothesis.