Serum Calcitonin in Patients with Chronic Renal Disease

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Abstract
The relationship between serum calcitonin, Ca-P metabolism and renal function was studied in 66 patients with chronic renal disease. Serum calcitonin was significantly elevated both in non-dialyzed patients and in patients on chronic hemodialysis. In the non-dialyzed patient group a highly significant inverse correlation was found between serum calcitonin and creatinine clearance. Serum concentrations of calcitonin correlated with those of P. In the dialyzed patients a significant inverse correlation was found between serum Ca and serum calcitonin. The elevated serum calcitonin in patients with chronic renal disease might be explained by a reduced renal degradation of calcitonin and/or an increased production due to stimulation by serum P.