Modeling and Identifying Optimum Designs for Fitting Dose-Response Curves Based on Raw Optical Density Data
- 1 September 1997
- journal article
- research article
- Published by JSTOR in Journal of the American Statistical Association
- Vol. 92 (439) , 1132
- https://doi.org/10.2307/2965578
Abstract
For raw optical density (ROD) data, such as those generated in biological assays using a 96-well plate reader, D-optimal designs are identified for a family of homogeneous nonlinear models with two parameters developed for fitting and studying dose-response curves. Further, within the class of k-point equally spaced and uniform designs, D-optimal designs are specified. Also, the D-efficiency of the D-optimal equally spaced and uniform k-point designs are compared to D-optimal design for 3 ≤ k ≤ 7. The efficiency robustness of these optimal designs with respect to initial nominal values of the parameters are investigated. In addition, D-optimal designs are derived for a family of heterogeneous nonlinear models.Keywords
This publication has 0 references indexed in Scilit: