Depression of Serotonin and Norepinephrine Levels in Brain Stem of Rabbit by Ethanol.

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Abstract
Ethanol was administered intravenously to rabbits in a dose of 2 g/kg and brain stem serotonin and norepinephrine measured spectrofluorometrically at intervals of 1/2 to 144 hours after the ethanol treatment. Both serotonin and norepinephrine were depressed to approximately 50% of control values 1 hour after administration and both returned slowly to normal values over a 4 to 6-day period. The parallel depletion of both neurohormones, persisting long after disappearance of the ethanol from the body, is reminiscent of the action of reserpine. Chronic administration of alcohol daily for 7 days also produced a 50% drop in both serotonin and norepinephrine levels in the rabbit brain stem.