Nafcillin Nephritis

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Abstract
To the Editor.— Methicillin, penicillin, and ampicillin have all been implicated in producing interstitial nephritis,1and these cases represent a doserelated hypersensitivity to penicillin derivatives.2We report a case of methicillin nephritis that recurred upon administration of nafcillin. Report of a case.— A 6-year-old white boy, with a 12-day history of fever, pain, and swelling of the left shoulder, had no prior history of drug allergy and had received penicillin for a sore throat some years previously. On admission his temperature was 39.5° C, with erythema, induration, and decreased range of motion of the left shoulder, and the white blood cell (WBC) count was 11,700/cu mm with 79% neutrophils and 1% eosinophils. Urinalysis showed no protein, cells, or casts and the creatinine clearance was 107 ml/min. The osteomyelitis and pyarthrosis of the left shoulder was found due to penicillin-resistantStaphylococcus aureus. Methicillin (250 mg/kg/day) was administered intravenously with

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